Measurement of acid strength of excipients by photoacoustic spectroscopy.

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Measurement of acid strength of excipients by photoacoustic spectroscopy.

Acid-base properties of excipient surfaces have been studied by photoacoustic spectroscopy (PAS) in the visible absorption range using seven acid-base indicators. The acid strength (Ho) of each excipient was determined from the PA spectral patterns of the indicators. The Ho values of silica-alumina, silica-magnesia and crystalline cellulose were determined to be between 3.3 and -3 .0, between 4...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1987

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.35.4255